After, upgrading my system to Tiger. I found that I could not click on any of the items on my desktop (They were accessabile via a finder window). During the upgrade, the desktop picture switched to a plain blue color. I could not switch the picture via System Preferences.
I was finally able to fix my issue by deleting the ~/Desktop/.DS_Store file and rebooting. This caused my desktop to rebuild itself. When the reboot came back, the image I had tried to select in System Preferences actually came up as well. Selecting of my desktop items returned as well. I'm feeling a little better about Tiger now :)
Note: if you are going to do this fix, you need to use Terminal to remove that file because its not visible via Finder.

